A pioneering study on biodegradable Zn-Mn-Ca alloys for intestinal application
作者
单位
1Beijing Advanced Innovation Center for Materials Genome Engineering、State Key Laboratory for Advanced Metals and Materials、School of Materials Science and Engineering、University of Science and Technology Beijing、Beijing 100083、China 2Institute of Materials Intelligent Technology、Liaoning Academy of Materials、Shenyang 110004、China 3Corrosion and Protection Center、Northeastern University、Shenyang 110819、China
关键词
收录来源
International Corrosion Congress · 第22届国际腐蚀大会
摘要
There have been many studies on the perspective Zn alloys for bone implants, but few for intestinal applications. Novel Zn -0.4Mn-xCa (x = 0, 0.05 and 0.1 wt.%) alloys are developed in this work for intestinal applications, in order to make use of proliferation effects of Mn and Ca elements on intestinal probiotics. Rat small intestinal crypt epithelial (IEC-6) cells can grow healthily on surfac es of all the alloys. Among them, the number of healthy cells on Zn-0.4Mn-0.1Ca is the largest. IEC-6 cell viabilities are over 160% (much higher than the benchmark of 75%) in 20%~100% extracts of Zn -0.4Mn-0.1Ca for 5 days. All the alloys can promote proli feration of intestinal probiotic (Lactobacillus acidophilus) and inhibit growth of intestinal pathogen (Escherichia coli). Among them, Zn-0.4Mn-0.1Ca alloy possesses greatest effect. With the increase of Ca content, the strength of the alloy increases. Zn -0.4Mn-0.1Ca alloy has the highest strength and a good plasticity among three alloys. It exhibits yield strength of 177 MPa, the ultimate tensile strength of 288 MPa, and elongation to failure of 41%. Since CaZn 13-Zn micro-cell controls corrosion rate, Zn -0.4Mn-0.1Ca with the highest volume fraction of CaZn 13 has the highest corrosion rate of 17.64 μm/year when immersed in simulated intestinal fluid for 28 days. Overall, the Zn -Mn-Ca alloys are promising candidates for intestinal implants.